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Freckling and skin sensitivity to sun 
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Old 02-07-2011, 04:35 PM   Post #1
Kadu
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Default Freckling and skin sensitivity to sun

Sulem P et al. (2007) . “Genetic determinants of hair, eye and skin pigmentation in Europeans.” Nat Genet 39(12):1443-52.


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rs1805007 This study assessed people from Iceland and the Netherlands for the presence of freckles and for sun sensitivity. Sun sensitivity was measured by the Fitzpatrick skin-type score, which assesses skin type, skin color, and reaction to sun exposure. The researchers found that each T at rs1805007 increased by 2.5 times the odds both that a person would freckle and be sun-sensitive. The SNP, which lies in the MC1R gene, is also associated with the odds of having red hair.

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Red hair comes in a wide range of shades, from strawberry blond to auburn. It is most common in Ireland, Scotland and other places where people have a significant proportion of Celtic ancestry. A study of people from Iceland and the Netherlands found that many cases of red hair are due to versions of the SNP rs1805007 in the MC1R gene. This gene encodes a protein involved in the production of melanin, the pigment that is in your hair, skin, and eyes. Each T at rs1805007 was found to increase one's odds of having red hair by about 6.1 times. Unsurprisingly, red hair is also associated with other pigmentation traits, such as light skin and a large number of freckles.
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I'm quite interested in knowing your genotype for this specific SNP
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Old 02-07-2011, 05:01 PM   Post #2
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I have CC, but that should be expected as I am non-European.
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Old 02-07-2011, 05:04 PM   Post #3
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Originally Posted by Berossus View Post
I have CC, but that should be expected as I am non-European.

Still, only two out of twenty three European individuals of my "extended level" list have CT, and none has TT.
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Old 02-07-2011, 05:07 PM   Post #4
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I am CC.
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Old 02-07-2011, 05:21 PM   Post #5
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My dad is redhead and he has some minute freckles. So I get this from him I am CT typical amount of freckling. As well for moles and freckles I get typical amount and I am AG. As for sensitivity to the Sun and freckles I am CC which is the typical odds.
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Old 02-07-2011, 05:24 PM   Post #6
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Originally Posted by Alberta View Post
My dad is redhead and he has some minute freckles. So I get this from him I am CT typical amount of freckling.
that is rs2153271 and the query here is for rs1805007.
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Old 02-07-2011, 05:35 PM   Post #7
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Freckling and skin sensitivity to sun CT for rs1805007. That explains the red beard
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Old 02-07-2011, 05:37 PM   Post #8
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Originally Posted by Fionnlagh View Post
Freckling and skin sensitivity to sun CT for rs1805007[IMG]chrome://snptips/skin/snp_present.png[/IMG][IMG]chrome://snptips/skin/snp_present.png[/IMG]. That explains the red beard

LOL, you're a crypto-ginger just like me then, CT here too.
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Old 02-07-2011, 05:49 PM   Post #9
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LOL, you're a crypto-ginger just like me then, CT here too.
Red haired people shouldn't live in places like Portugal.
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Old 02-07-2011, 05:59 PM   Post #10
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Originally Posted by Fionnlagh View Post
Red haired people shouldn't live in places like Portugal.
They don't... but we have our oddities like this bullfighter here:



I'm CC, just like the rest of us normal folks
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